A Tutorial on Pharmacodynamic Scripting Facility in Simcyp

The Simcyp Simulator provides a framework for mechanistic Physiologically-Based Pharmacokinetic/Pharmacodynamic modeling of potentially interacting drugs. It also provides a scripting facility, using the Lua language, for developing customized pharmacodynamic and toxicity models driven by drug concentrations at the site of action. We present an overview of the scripting facility including the scripting language, the editor, and how scripts are embedded within the Simulator. Examples incorporating differential equations and including inter-individual variability on parameters are presented.